Region-of-Interest Analyses of GLP-1 RA Effects on Food Cue Reactivity Seven studies employed ROI-based analyses
A GIP-GLP-1R coagonist is now used to treat people with T2D and produces substantial weight loss, resulting in its approval for treatment of obesity in 2023
Accordingly, claims of long-term structural renoprotection should be interpreted cautiously until kidney-focused trials and longer follow-up data confirm benefits on hard renal endpoints (eGFR slope, ESKD)
Obesity is particularly significant, as excess adipose tissue increases lymphatic load and may directly impair lymphatic vessel function through inflammatory mechanisms
However, during the first few months of the treatment, Tanya struggled to sleep, felt sick all the time, had headaches and even started to lose her hair, which might not be directly due to the drug but is a potential side effect of rapid weight loss
In the secondary analysis measuring progression to exudative AMD at 10 years compared with OWLD use, GLP-1 use (RR, 0.70) and no weight loss med use (RR, 0.52) were associated with a lower risk of progression to exudative AMD