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SGLT2 inhibitors should not be used in the presence of severe illness, ketoacidosis, ketonuria, prolonged fasting, or during surgery

Reduced TNSALP activity affects the hydrolysis of phosphate esters including substrates like PLP and contributes to the decreased ALP levels observed in HPP

Miljkovi, A

[1] [3] Beyond glycemic control, these medications slow gastric emptying, which prolongs satiety and reduces appetite through central nervous system pathways

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For more formal quantification, validated screeners include the Physical Activity as a Vital Sign questionnaire 136 and the International Physical Activity Questionnaire