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Notably, Through a feedback mechanism, mTORC1 inhibition may momentarily increase mTORC2 signaling, causing temporary metabolic disruptions during the first phase of treatment (224), which can transiently disrupt metabolism and frequently leads to hyperlipidemia, necessitating concomitant lipid-lowering therapy (237239)

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Tesamorelin: Specialized but Limited Tesamorelin (brand name Egrifta) is a GHRH analog approved by Health Canada for the reduction of excess abdominal fat in adults with HIV-associated lipodystrophy

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