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However, their unsatisfactory therapeutic efficacy due to poor skin penetration, transient therapeutic effects, and risks of cutaneous atrophy or tachyphylaxis with prolonged use has constrained their clinical applications [3, 4]

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This study population was divided into two cohorts: (1) Semaglutide cohort 25,843 patients prescribed semaglutide, and (2) Non-GLP-1RA anti-diabetes medication cohort 562,006 patients prescribed non-GLP-1RA anti-diabetes medications but not semaglutide