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Metabolites are the ultimate executors and precise regulators of biological functions, and their changes directly reflect the real-time physiological and pathological status and energy metabolism of the cells [266]

COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness

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IGF-I has been associated with the activation of the MAPK and PI3K signaling pathways (64)

For example, women often reach toxic BAC levels with fewer drinks than men because of differences in body composition and metabolism