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Oxidation products represent another significant impurity class

Semaglutide, the active ingredient in both Ozempic and Wegovy is currently being evaluated in phase 3 trials for cardiovascular outcomes in diabetes patients, heart failure with preserved ejection fraction, morbidity and mortality in obesity, Alzheimers, and obstructive sleep apnea (OSA)

While the sun helps produce vitamin D, UV radiation also breaks down folate in the skin

It appears to activate the ghrelin receptors (GHSR) which appear to trigger growth hormone synthesis

This means it activates two naturally occurring hormone pathways at once