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In PD, early GSH depletion in the substantia nigra precedes dopaminergic neuron loss, suggesting that redox dysfunction may be an inciting event that leads to eventual neuronal damage ( 2 Mechanisms of redox regulation in the CNS 2.1 GSH as an antioxidant in the brain The brain, being one of the most metabolically active organs in the body, requires a large share of oxygen relative to its mass

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