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HT-1080 N TP53 (p53) and CDKN1A (p21) gene disrupted (KO) cell lines generated using CRISPR-Cas9 genome editing were described previously (Tarangelo et al, 2018)

It's a master regulator

4A-4Bshow frequency (kHz), and the y-axis shows ABR threshold shift (dB SPL).FIGS

Moreover, this effect is most pronounced in the oldest flies (30 days old at time of APAP administration) and is observed in both males and females (Fig