You might know them by brand names like Ozempic, Wegovy, Mounjaro or Zepbound
Note any side effects and their severity to spot trends and inform dose decisions
They were the main reason the trials titrate slowly
Hart DR, Fabi SG, White WM, Fitzgerald R, Goldman MP
GLP-1 receptor agonists e.g., semaglutide, liraglutide commonly cause gastrointestinal adverse effects such as nausea, vomiting, diarrhea, constipation, and abdominal discomfort, especially during dose escalation, less common risks include pancreatitis, gallbladder disease, and hypoglycemia mainly with insulin sulfonylureas
This gradual titration approach is consistent with the prescribing philosophy applied to other incretin-based therapies in the UK, where slow escalation is used to improve tolerability and encourage long-term adherence