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In contrast, oral supplements must pass through the digestive tract, where factors such as stomach acid, enzyme activity, and gut health can affect the absorption rate

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It was FDA-approved in 2010 as a weight loss medication for Netherlands HIV patients suffering from lipodystrophy, a condition that leads to an accumulation of fat (adipose tissue) in the abdominal area

This places the interaction firmly in the "minimal clinical significance" tier for healthy adults on standard doses of both medications