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In addition to mechanical, peptide and neurotransmitter induced GLP1 secretion

As a refined carbohydrate with very little fiber, fat, or protein, it causes a quick rise in blood glucose, triggering a strong insulin response that may be followed by fatigue or shakiness

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This also ensures that the medication absorbs well into the tissue

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doi: 10.1038/s41598-022-14245-3 47