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Receiver Operating Characteristic (ROC) analysis, using a non-parametric method, evaluated the diagnostic potential of biomarkers, with criteria including an area under the curve (AUC) 0.8 and determination of optimal cut-off points with thresholds set at a log2 fold change 1.5, p-value 0.05

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The central contribution of neuroglia to neuropathology was already recognised by Rudolf Virchow, who considered the interstitial tissue (i.e

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Research is ongoing, and there are signals from observational studies and reviews that GLP-1 therapies could influence neuroinflammation and neurodegenerative riskbut they are not currently indicated to treat Alzheimers or Parkinsons outside clinical trials, and some trials have not met primary endpoints