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[ 8 ] In humans, one study found that DSIP reduced circulating ACTH levels, while another found no effect on CRH-stimulated ACTH and cortisol secretion

One Michigan obesity physician put it bluntly: society has trained us toward beauty standards that arent health standards, and an injection that makes starvation easy demands more caution, not less

Bibcode:2015NatCo...6.7174Y

Adequate protein intake (minimum 1 gram per pound of goal body weight daily) and resistance training help preserve muscle

The most common berberine side effects are: Nausea Vomiting Bloating Constipation Diarrhea Stomach pain These effects are often mild, temporary and can improve as the body adjusts

That is not a secondary benefit