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One possible scenario is the metabolic cofactor NADPH, which is known to be required not only for lipid synthesis but also for the function of antioxidant reductases, such as glutathione reductase (GSR) and thioredoxin reductase (TXNRD) 86

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Neonate 79 , 172179 (2001)

To view a copy of this license, visit About this article Cite this article Wan, L., Li, Y., Zhang, Z

If certain microbial changes consistently precede disease onset by years (as constipation does in PD), it strengthens the case for causality and prevention

It points to new avenues for developing targeted therapiessuch as molecules that can restore microexon inclusion or compensate for its absence