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Glutathione (GSH) is the highest concentration non-protein thiol in mammalian cells and is present in concentrations of 0.5 to 10 mM

During the neuroinflammatory process, microglia get over-activated and oversensitive, and they can trigger the release of several cytotoxic molecules like tumor necrosis factor (TNF), pro-inflammatory cytokines (e.g., IL-1, IL-6, IL-18), and interferon- (IFN-), and oxidative metabolites (e.g., reactive nitrogen and oxygen species, and nitric oxide) [13]

Heringa M B, Schreurs R H, Busser F, Van Der Saag P T, Van Der Burg B and Hermens J L 2004 Toward more useful in vitro toxicity data with measured free concentrations

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doi: 10.1093/JAS/SKAD281.208 36 DahlhoffC.DesmarchelierC.SailerM.FrstR