The less sensitive glucocorticoid receptor (GR) comes into play in the hippocampus, hypothalamus, and pituitary gland under stress and therefore high glucocorticoid concentrations
Timing, plan participation, and clinical criteria still matter
It is particularly useful for studying receptor desensitization, sustained signaling pathway activation, and for comparative studies with other GLP-1 receptor agonists
But dont sweat it
Recent studies suggest that glucagon receptor signaling is disrupted in NAFLD, indicating that supra-physiological glucagon receptor agonism might represent a new NAFLD treatment target
If youre transitioning off a compounded dose , that supervision is especially importantyour provider will look at your prior dose, how long youve used it, and your response to decide whether you continue at a comparable dose or restart the standard step-up schedule to keep side effects manageable