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47 Blood Sugar Regulation: These medications also improve blood sugar control by stimulating the pancreas to release insulin (which lowers blood sugar) and suppressing the release of glucagon (which raises blood sugar) when blood glucose levels are high

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In mice ablation of the POMC gene (POMC-null) results in viable animals, even though they have minimal adrenal tissue and undetectable glucocorticoids due to the lack of ACTH

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Blood 102:389a, 2003