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Sources Chubb, B., Gupta, P., Gupta, J

Journal of Diabetes and Its Complications

Eur J Pharm Biopharm 63:134139 [DOI] [PubMed] [Google Scholar] Jiang Q, Christen S, Shigenaga MK, Ames BN (2001) Gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention

3 Epigenetics Curcumin acts as a potent multi-target epigenetic modulator influencing gene expression through four major mechanisms: it inhibits DNA methyltransferases DNA (Cytosine-5)-Methyltransferase 1 DNA (Cytosine-5)-Methyltransferase 3 Alpha, DNA (Cytosine-5)-Methyltransferase 3 Beta (DNMT1, DNMT3A, DNMT3B), leading to demethylation and reactivation of silenced tumor-suppressor genes

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Super-responders: Patients achieving results at 0.25-0.5 mg pay less monthly indefinitely for maintenance