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Qiang JK, Lipscombe LL, Lega IC (2020) Association between diabetes, obesity, aging, and cancer: review of recent literature

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For the survival experiment, mice were checked daily and were culled when they showed visible distress symptoms such as weight loss of 10% or more, ascites equivalent to full-term pregnancy, reduced or slow activity, pale feet, hunching, piloerection, closed eyes and isolation from cage mates

To identify the full extent of the differential signaling responses to ligand stimulation between WT-IR and L973F-IR, we also compared the fold changes of each phosphosite between basal and stimulated conditions in these 2 cell types for both up- and downregulated phosphorylation in a volcano plot (Figure 3C)

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