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Here, we provide the first evidence of improved healthspan and age-related survival with a therapeutic mAb by demonstrating that treatment with an IGF-1R antagonist in older mice significantly and preferentially improves several indices of healthspan, reduced death from neoplastic disease, and increased mean and median lifespan in females

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This information is crucial for researchers designing controlled experiments

they are being studied as metabolic medications that may affect outcomes in hormone-sensitive disease

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Methods Enzymol 559:127139 Shao Y, Xue C, Liu W, Zuo S, Wei P, Huang L, Lian J, Xu Z (2022) High-level secretory production of leghemoglobin in Pichia pastoris through enhanced globin expression and heme biosynthesis