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Importantly, in DIO mice, the Gcg/T3 conjugate leads to substantial T3 accumulation in the liver which results in: a reduction of plasma cholesterol to same degree of that elicited by free T3, a reduction of hepatic cholesterol greater than that of glucagon or free T3, and an absence of free T3-mediated increases in food intake and locomotion all while retaining additional enhancements in energy expenditure associated with systemic T3 agonism [54]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Brown JC, Pederson RA