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Notably, fiber photometry also revealed that systemic administration of GLP-1 [149] and liraglutide [148] does not affect the activity of ARC AgRP/NPY neurons, emphasizing how findings from patch-clamp electrophysiology experiments on hypothalamic slices can differ from the situation in vivo

Kosinski and colleagues constructed a variant of OXM, OXMQ3E, that was unable to activate the GCGR by changing the third amino acid residue from neutral glutamine to acidic glutamate (38)

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[DOI] [PubMed] [Google Scholar] [137].Zhu K, Kakkar R, Chahal D, Yoshida EM, Hussaini T

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