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216 In addition, PRMT4-catalyzed asymmetric dimethylarginine (ADMA) has been reported to bind to NOS as a ligand, leading to NOS dysfunction, resulting in decreased cerebral blood flow and aggravating AD, which can be reversed by inhibition of PRMT4

These medications are intended to be used in combination with diet and exercise to manage blood sugar levels in individuals with type 2 diabetes

Constipation: In some cases, constipation may occur, though it is generally less common than other gastrointestinal issues

J., Hultman, C

[47]Da Silva, Eunice S

Moreover, several large-scale clinical trials 6,7,8,9,10 such as LEADER, SUSTAIN-6, and REWIND have demonstrated that GLP-1RAs can reduce the incidence of MACEs in patients with T2D and established cardiovascular disease or high cardiovascular risk