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It is typically secreted by the gut in response to meal consumption

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If a serious reaction occurs, Emgality should be discontinued and appropriate therapy administered

The idea is that even if the peptide is broken down before it reaches the bloodstream, it might exert some beneficial actions on the gut's epithelial cells during its passage

The differences in weight reduction against each comparator were: 2.5 and 3.5 kg vs placebo, 1.4 and 4.2 kg vs sitagliptin, and 4.7 and 6.4 kg vs insulin glargine with 0.5 and 1 mg doses of semaglutide, respectively

doi: 10.1111/REGO.12494 222 ChristensenTJensenMDKluthMKristinssonGHLynggaardKLgreidPet al