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for example, glutamine/glutamate is a core metabolic fuel for DCs function, glutamine provides ATP and metabolic intermediates to DCs through conversion to glutamate and -KG into the TCA cycle, and in TME, DCs compete with tumor cells for glutamine as a nutrient (84)

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Identifying predictive biomarkersincluding genetic variants (e.g., Hp genotype), markers of mitochondrial function, inflammatory cytokine profiles, and integrated metabolic signatureswill enable stratification of patients according to likely benefit

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doi: 10.1038/s41598-021-89225-0 130