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The neurological aspects of the disease are thought to arise from the accumulation of methylmalonyl- CoA due to the requirement of B 12 as a cofactor to the enzyme methylmalonyl-CoA mutase
Framing the conversation around absolute risk, which stays low for any individual even when the relative risk looks large, keeps it accurate
The National Institutes of Health study reports that between 1.5% and 15% of the public has a deficiency
The key is to confirm the "pernicious" part of the name, which refers to the underlying autoimmune attack
[8] Although not an absolute contraindication, patients with coronary artery disease or unstable angina should only use B-Complex injections containing niacinamide under physician supervision, since high-dose niacin supplements have been linked to arrhythmias in such patients
Common lipotropic ingredients include methionine, inositol, choline, and vitamin B12
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