eli lilly retatrutide study Phase 3 obesity trial results 2026 Eli Lilly's retatrutide cuts weight

Finally, among GLP-1 RA, the Effect of Efpeglenatide on Cardiovascular Outcomes (AMPLITUDE-O) trial demonstrated a beneficial effect of weekly efpeglenatide on MACE and on a composite kidney outcome (decrease in kidney function or severe albuminuria) [247]

But viewing glucose isn't enough

Menopause, sleep disruption, vasomotor symptoms, insulin resistance, body-composition changes, thyroid dysfunction, low testosterone, and chronic stress signaling can all influence how patients feel, recover, move, sleep, and maintain metabolic health

Enter gastric inhibitory polypeptide (GIP) the second agonist

While this trend is common, the degree of appetite suppression isnt identical for everyone

Add one high-fiber food at a time and give your body a week to adjust