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46 In the rare instances that medication cessation does not lead to cholestasis resolution, cholestyramine or ursodeoxycholic acid has been used, followed by rifampicin and opioid antagonists if the first-line agents fail

in vitro, in silico and in vivo studies

While BSO exhibits some anti-tumor activity, its clinical investigation is still very limited, necessitating additional research to determine its safety and efficacy in cancer therapy