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As a result, the increased secondary BAs can activate TGR5, which increases L-cells and GLP-1 secretion by inhibiting the RhoA/ROCK pathway and inducing YAP activation [157, 203]

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Think of it like blood pressure medicationobesity is a chronic condition that requires ongoing management

520 Subsequently, the study observed that treatment with liraglutide, both in vitro (cell culture models) and in vivo (mouse models), inhibited the tumor formation and metastatic capabilities of pancreatic cancer cells by activating GLP-1R

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2 Gut Microbiota Affects GLP-1 The human gut, commonly known as the gastrointestinal (GI) tract, possesses more than 1,000 microbial species that form a complex ecological community known as the gut microbiota