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Department of Genetics and Clinical Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland Abstract Reactive oxygen and nitrogen species can be generated endogenously (by mitochondria, peroxisomes, and phagocytic cells) and exogenously (by pollutions, UV exposure, xenobiotic compounds, and cigarette smoke)

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Simon, C., Soga, T., Ahemad, N., Bhuvanendran, S., & Parhar, I

However, an elevation of B12 in ones serum can be tied to the MTHFR gene variation , as those with the MTHFR gene variation may be unable to properly use non-methylated B12