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Critically, low doses (approximately 5x baseline levels) were effective while high doses were not, suggesting a therapeutic window

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Formulation pH is critical: GHK-Cu is most stable at pH 5.06.0

Notably, over the subsequent 6 days, we observed a sustained body-weight-lowering effect after infusion of GLP-1MK-801, but not semaglutide, suggesting that the targeted inhibition of NMDA receptors in GLP-1 receptor-positive neurons might promote sustained changes to the defended level of adiposity