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A study has reported that acetaminophen is a very weak inhibitor of COX, which does not inhibit neutrophil activation ( in vivo and in vitro whole-cell patch-clamp recordings have shown that acetaminophen metabolite AM404 directly inhibits excitatory synaptic transmission via TRPV1 receptors expressed on terminals of C-fibers in the spinal dorsal horn

Neuen BL, Fletcher RA, Heath L, et al