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At least, nine members of TRP superfamily are activated by oxidative stress including TRPM2, TRPM7, TRPA1, TRPC3, TRPC5, TRPC6, TRPV1, TRPV3, and TRPV4 (Ogawa et al., 2016)

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In humans, many circadian-regulated rhythms exhibit attenuated amplitude and phase shifts in older age (Figure 2 illustrates schematically some documented changes: rhythms of locomotor activity (rest-activity cycle), core body temperature, hormone secretion (e.g., melatonin at night, cortisol in the morning), SCN neuronal firing rate, and even daily metabolic indicators like plasma glucose all show diminished oscillation amplitudes in older adults compared to younger adults

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Finally, CLO prevented lung tissue damage and restored the destruction caused by CY, reducing epithelial desquamation and relieving congestion and inflammation

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