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By regulating the expression of the pro-invasive molecule alanyl aminopeptidase (Anpep) on the surface of endothelial cells, hepatic invariant-NKT (iNKT)-derived IL-22 modulated endothelial cell permeability and favored the seeding of circulating cancer cells in the liver, promoting CRC liver metastases (144)

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increase to 500 mcg for Weeks 512 as tolerated