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More recently, Lilly reported topline phase 3 TRIUMPH-1 results in adults with obesity or overweight without diabetes

2000 May 12;285(2):99-102

Wegovy, Mounjaro, Saxenda and others all work through similar mechanisms but differ meaningfully in how well most people tolerate them

But what happens with you go off these medications? Studies suggest most patients regain the weight they lost after halting semaglutide, and in one trial examining short-term use of Wegovy, half the participants who stopped the medication regained 70 percent of their weight after 48 weeks

Consider treatment response and tolerability when selecting the maintenance dosage Cardiovascular risk reduction maintenance dose: Either 2.4 mg (recommended) or 1.7 mg once weekly, based on patient response and tolerance

Medications like semaglutide and tirzepatide have helped millions achieve significant health milestones