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It achieves this by translocating from mitochondria to the cell membrane and participating in the reduction of COQ10 to COQ10H2

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Abbreviations: BSO, buthionine sulfoximine

The genotyping primers are listed in Table 1

2016;68(Suppl 3):1-4 36

This altered pharmacokinetic profile increases nausea intensity and duration the most common dose-limiting side effect and shortens the effective half-life, potentially requiring more frequent administration to maintain stable receptor occupancy