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The fit was generated using GraphPad Prism (Version 10.6.0) using a non-linear regression curve fit with a one-site specific binding model and a single dissociation constant (KD) was computed (Supplementary Figures 31, 33 and Tables 14,16)

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For diabetes management, semaglutide can be combined with metformin (which improves insulin sensitivity through distinct mechanisms), SGLT2 inhibitors (which promote urinary glucose excretion and offer cardiovascular and renal benefits), or basal insulin for patients with significant insulin deficiency

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