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Key finding: AOD 9604 increased type I collagen synthesis 2.1-fold and decreased MMP-1 expression by 64% in human fibroblasts
The diagnostic process typically involves: Clinical history taking, focusing on symptoms (fatigue, neurological changes, dietary habits) Physical examination for signs of anaemia or neurological impairment Blood tests including full blood count, serum B12, and often folate levels Additional investigations such as intrinsic factor antibodies or parietal cell antibodies if pernicious anaemia is suspected For borderline results, additional tests like holotranscobalamin (active B12) may be considered NICE guidance recommends that treatment should commence based on clinical presentation if neurological symptoms are present, without waiting for laboratory confirmation, as delays can result in irreversible nerve damage
About the reviewerView full bio Dr Doug McKechnie, MRCGP Medical Writer MA, MBBS, MSc, DRCOG, MRCP(UK), MRCGP(2021), FHEA Dr Doug McKechnie is an NHS GP working in London
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IteMild redness or soreness at the injection site may occur but typically resolves quickly
Nicotinamide N-Methyltransferase: More than a vitamin B3 clearance enzyme (in Eng)
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