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This ultimately led to a sharp increase in lipid peroxidation levels in neurons

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18 The SYNERGY-NASH (A Study of Tirzepatide [LY3298176] in Participants With Nonalcoholic Steatohepatitis) trial, 19 a phase 2b dose-finding study, randomized 190 patients with biopsy-confirmed MASH and stage 2 or 3 fibrosis to receive weekly injections of the GLP-1 and GIP dual agonist tirzepatide 5 mg, 10 mg, or 15 mg or placebo for 52 weeks

As the field moves beyond rapid weight loss toward sustainable metabolic disease modification and long-term cardiometabolic health , the need for new approaches has never been clearer

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The authors did not fully agree that the subgroup analyses of CVOTs demonstrate a consistent reduction in MACE across a range of previous CV events