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MOTS-c has the most direct disc-specific evidence, with rat studies showing preserved disc height and reduced degeneration scores

Magnesium is a crucial intracellular cation cofactor for numerous enzymes involved in insulin metabolism [144]

Until larger human trials are available, most clinicians recommend empty-stomach administration for both oral and sublingual routes

Prospective patients should prepare the following documentation: Neurological Imaging: Recent MRI, fMRI, or PET scans of the brain to evaluate neural integrity and inflammation in the hypothalamus, amygdala, and prefrontal cortex

Second, advanced technologies such as single-cell transcriptomics and proteomics are needed to define inflammation subtypes and enable individualized anti-inflammatory treatments