Doctors are prescribing it anyway.
Variants in genes affecting liver metabolismparticularly those influencing cytochrome P450 enzyme activitydetermine how quickly your body breaks down warfarin and other anticoagulants
PubMed, Gejl, Michael, et al
161,167 Small molecule GLP-1RAs Currently, most GLP-1RAs are based on proteins or peptides, meaning they are large molecules typically administered via injection
A recent study from the Cleveland Clinic showed that genetic variants also play a significant role in the response to GLP-1 RAs, like semaglutide, for weight loss
Understanding this overlap helps explain why some patients report worse GI side effects mid-to-late cycle and why hydration and meal timing become especially important during menstruation