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To ensure that findings are generalizable, key next steps will be to replicate and extend this work with variations of the target (e.g., gender, race/ethnicity, prior attempts at weight loss, cost paid for medication) and diverse groups of participants, both in terms of participant demographics and preexisting knowledge of GLP-1s (e.g., general population, eligible patients, healthcare professionals)

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Notably, CYP27B1 is also expressed in extra-renal tissues such as the placenta and prostate, where it facilitates local synthesis of 1,25(OH)D to modulate cellular functions via paracrine or autocrine signaling [96, 99]