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Active drug or placebo were self-administered at the onset of OFF-periods and the primary endpoint was the change in UPDRS motor scores from pre-dose to 30 min post-dose assessed during an in-clinic OFF-period at week 12

Insights from a mediation analysis of the empa-reg outcome trial

Rare serious adverse events: pancreatitis, gallbladder disease, acute kidney injury

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Some cats are more prone to vitamin B12 deficiency due to underlying health issues or genetic factors affecting absorption