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Finally, 17 studies included 3420 patients were included

The redox cycling enzymes thioredoxin, thioredoxin reductase, sulfiredoxin, peroxiredoxin, GSH peroxidase, superoxide dismutase 1, and catalase, and several GSH S-transferases, which are the enzymes mediating the elimination of ROS, are all Nrf2 targets (242)

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9 OFF-LABEL USES OF HYDROQUINONE Disorders of hyperpigmentation including but not limited to chloasma, melasma, ephelides, and solar lentigines 5,6,8 HYDROQUINONE DOSING Topical application to affected areas twice a day

As shown by Irene Martinez de Toda et al 2019 data, patients with dementia have a reduction in both the enzymes (GR and GP) that recycle glutathione