Zheng J, Xie Y, Ren L, Qi L, Wu L, Pan X et al (2021) GLP-1 improves the supportive ability of astrocytes to neurons by promoting aerobic glycolysis in Alzheimers disease
The average retail price for a box of four 5 mg/0.5 mL prefilled pens is around $1,470
Generic semaglutide is expected within the next few years as patents expire, which could reduce costs by 80-90%
Tiredness may result from reduced caloric intake due to appetite suppression, gastrointestinal side effects limiting food consumption, dehydration from vomiting or diarrhea, changes in blood glucose levels, or metabolic adjustments during significant weight loss
Journal of Clinical Investigation
The mechanism is indirect, primarily driven by rapid weight reduction and nutritional deficiencies rather than direct drug effects