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The weight-loss-independent hepatoprotective benefits of semaglutide are orchestrated by intrahepatic sinusoidal endothelial GLP-1 receptors: Cell Metabolism The weight-loss-independent hepatoprotective benefits of semaglutide are orchestrated by intrahepatic sinusoidal endothelial GLP-1 receptors: Cell Metabolism Semaglutide improves metabolic liver disease partly via intrahepatic GLP-1 receptors The hepatic GLP-1R is expressed within T cells and endothelial cells Liver sinusoidal endothelial cell GLP-1 receptors transduce hepatic GLP-1 action LSEC GLP-1Rs communicate metabolic signals to a wide range of intrahepatic cell types