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Unlike aggressive diets or supplements that often deplete the body, MOTS-c optimizes the bodys natural metabolic processes

[DOI] [PubMed] [Google Scholar] Castillo J., de la Iglesia A., Leiva M., Jodar M., Oliva R

Dose timing relative to meals, injection technique accuracy, and medication storage also influence bioavailability and response consistency

the mixture should be refrigerated if not used immediately

Why to be leery of online claims The lack of conclusive clinical evidence regarding berberines potential weight-loss benefits is why, in 2022, Frontiers in Nutrition published a systematic review and meta-analysis of 49 studies and concluded that "although [berberine] may affect weight, it does not have a statistically significant and considerable effect" on body mass index