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Future clinical trial designs should consider the following aspects: (1) Selecting appropriate formulations: Priority should be given to nanoformulations or chemically modified compounds that have demonstrated optimal brain targeting efficiency and safety in preclinical studies, as opposed to conventional quercetin supplements
Another polyamine, putrescine, is naturally produced in peri-ovulating women and decreased in women with age-related infertility, demonstrating the role of putrescine in ova production and its potential for improving ova quality as a treatment for infertile women of advanced maternal age 100
FOXO transcription factors play a crucial role in the regulation of processes related to aging and longevity, with increasing evidence suggesting their significance in the pathogenesis of neurodegenerative diseases (NDDs)
