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In five passive loading liposome systems, protonation of drug molecules significantly reduces their binding to phospholipid membranes and even drastically alters the morphology and vesicle size in multivesicular liposomes

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This side effect often improves over time

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Monitor Performance Signals, Not Just Body Weight If body weight is decreasing while power, pace, recovery, or training tolerance are also declining, this is a clear signal of insufficient fueling