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101 The evidence strongly implies that RAF-MEK-ERK pathway serves as an upstream modulator of NADPH oxidase, thereby implicating its involvement in the formation of NETs through the activation of NADPH oxidase and up-regulation of anti-apoptotic proteins

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At the same time, Smac (second mitochondria-derived activator of caspase) inactivates caspase-inhibiting X-linked inhibitor of apoptosis protein (XIAP), which functionally contributes to the recruitment of caspase-3 and caspase-7 [82]